A "zombie plague", along the lines of the disease from 28 DAYS LATER, spreads, and a group of civilian survivors on a bus are being led by the military to a safe haven. However, they get attacked and only three of them escape. Ten years later we see that only the two men are left alive-and that one of them has raised the daughter of the woman who was with them. We learn later that she had to be killed when she was infected. The guys, Patrick (Matthew Fox) and Jack (Jeffrey Donovan) live in separate houses and do not communicate with each other. It's not until one of the new creatures poses a threat and Patrick stops drinking that they agree to help each other survive this new invasion.
Although Matthew Fox is basically rehashing his Jack character from LOST, it does offer an interesting twist to the zombie genre, with showing what the infected people from a decade ago have transformed into (sort of these Gargoyle-looking creatures). The movie also has a decent production value.
EXTINCTION is sort of a zombie filled version of ROBINSON CRUSOE. Recommended.