This is a rather odd cross-over series. The six issues are brief on the main story (20 pages) since there's a short backup story to introduce another IDW series. Agents Mulder and Scully are sent to investigate some weird murders in Alaska along a truck route. The truckers are all decapitated. There are already a pair of agents there--Frenchy, who calls him "Spooky" Mulder and his partner, who actually turns out to be a distant descendent of one of the vampires we're introduced to later. They think it's the work of a serial killer who hasn't been caught-- but Mulder thinks it's probably a vampire. And things get worse once Agent French gets transformed...
This is an odd cross-over, totally unnecessary, of course--but it works, particularly if you're a fan of both franchises. Recommended.