In this new adaptation of the Marvel-comic character, Peter Parker is a high schooler being raised by his Uncle Ben and Aunt May. He discovers a briefcase that belonged to his scientist father and in a hidden compartment are notes with various equations. He wants to find out what happened to his parents (who were killed in a plane crash) and goes to his father's former partner, Curt Connors (Rhys Ifans of HANNIBAL, NEVERLAND). Connors is a herpatologist working at Oscorp and is determined to find a way to improve humanity, especially by regrowing limbs. He's missing his right arm. Parker sneaks in as an intern--and realizes that the girl he likes, Gwen Stacy (Emma Stone) is Connor's #1 intern. Parker gets away from the group and finds himself in a weird room filled with glowing spiders. One of them bites him. He awakens on a subway car and has an incident with some other passengers--least to say, his spider powers are evident. Things change when Uncle Ben is shot by a robber Parker failed to stop--and he goes on a quest to find the murderer, who has long blonde hair and a star tattoo on his hand. Rumors of a vigilante "Spiderman" begin to circulate--and Captain Stacy of the police (Denis Leary) doesn't like this one bit. He wants Spider-Man captured. Meanwhile, Connors and Parker get to know each other a bit more--and Parker gives Connors his father's formula, which seems to work. Connors is under pressure from his boss (an unseen Normal Osborne) to do human testing after the testing works on rats--and he injects himself with the green serum, transforming into The Lizard. The whole rest of the movie is Spider-Man trying to stop the Lizard's plan of transforming all of New York into creatures.
This movie is better than all three Raimi SPIDER-MAN movies combined. It's serious, never boring and has much more an emotional punch than the previous outings. Best of all, Spider-Man has his mechanical web-shooters, not webs coming out of his hands. Highly recommended.