Dr. Heiter (Dieter Laser) is a retired surgeon who specialized in separating conjoined twins. Now he's insane and wants to go in the other direction-- splicing people together.
The beginning of the movie introduces American college girls Lindsay and Jenny, who are taking a trip across Europe. Their car breaks down and so they go for help, stumbling upon Dr. Heiter's secluded house/laboratory. He drugs them and they awaken to find themselves strapped to surgical tables. On a nearby table is also a Japanese guy who is pissed. The crazy doctor explains, with a powerpoint presentation, how he will perform surgery on them, stringing them together mouth-to-ass, so that they'll be like a human centipede. Of course, they are terrified.
This is an unsettling movie, up there with the original versions of LAST HOUSE ON THE LEFT and I SPIT ON YOUR GRAVE. The movie's strength is that it doesn't get too overly graphic--we don't see the surgery itself, just the aftermath with the trio bandaged together. The power of the movie is the sick idea and feeling sorry for the victims. Recommended.