Angela Vidal (Jennifer Carpenter of DEXTER, EXORCISM OF EMILY ROSE) is a newbie reporter doing a story on the fire department in Los Angeles when they get a late night call to an old apartment building. Two cops are already there when they show up and one gets his neck bitten by a crazy, deranged looking old lady. There's some type of contagious disease, like a hyper version of rabies. Before they can leave, though, the government shows up and seals up the building, posting soldiers with machine guns outside. They can't leave-- and more people are changing into these maniacs.
Carpenter is great in this part and goes through a wide range of emotions. Johnathon Schaech (ORGANIZM, PROM NIGHT) is George Fletcher, one of the two firemen the reporter follows and he's a hoot. You think he's going to be the main character and hook up with Angela but he pretty much has the "Dallas" role in ALIEN. It's not good what happens to him...or to many of the others.
This is another movie shot as if the viewer is watching a documentary, like DIARY OF THE DEAD or CLOVERFIELD but not pulled off as well stylistically. Nevertheless, once it gets going and we're in the midst of the story it sucks you in and is unrelenting. Someone dies about every five minutes. Think of 28 DAYS LATER if everything took place inside one building.
The movie also made me jump a few times in my seat, something that doesn't happen too often to this jaded viewer. QUARANTINE is one of the better horror movies of 2008.